Consider Azithromycin. This macrolide antibiotic offers similar broad-spectrum coverage against common HSG-related pathogens as doxycycline, demonstrating comparable efficacy in reducing infection risk in several studies. It’s a single-dose regimen, improving patient compliance compared to doxycycline’s multi-day course.
Alternatives for Patients with Allergies or Contraindications
Amoxicillin-clavulanate provides another viable option. This combination antibiotic effectively targets a wide array of bacteria, offering robust protection against infection. However, it requires a multi-day course. Clinicians should carefully assess patient allergy history.
Cefazolin, a first-generation cephalosporin, represents a strong choice for those with penicillin allergies, providing excellent gram-positive coverage. Administered intravenously or intramuscularly, it’s generally well-tolerated but may not be as effective against some gram-negative organisms. Always consult with the patient’s physician to discuss the best antibiotic choice for their individual circumstances.
Considerations Beyond Antibiotics
Strict aseptic techniques during the HSG procedure remain paramount in infection prevention. Meticulous adherence to sterilization protocols significantly reduces the risk of infection, regardless of antibiotic prophylaxis. Proper patient preparation and post-procedure care also contribute to optimal outcomes.


