Cephalexin dosage requires adjustment for patients with impaired kidney function. Reduced kidney function means the body eliminates cephalexin more slowly, increasing the risk of side effects.
Dosage adjustments are usually based on creatinine clearance (CrCl), a measure of kidney function. Here’s a general guideline, but Always consult a physician or pharmacist for personalized recommendations:
- CrCl ≥ 50 mL/min: Normal dosage may be used. Monitor for side effects. CrCl 30-49 mL/min: Reduce the dosage by approximately 50%. This usually involves giving half the standard dose at the standard intervals. Careful monitoring is recommended. CrCl 10-29 mL/min: Reduce the dosage by approximately 75%. Administer one-quarter of the standard dose at the usual intervals. Close monitoring is crucial. CrCl < 10 mL/min: Cephalexin is generally contraindicated or requires significant dosage reduction under the direct supervision of a nephrologist. Alternative antibiotics are often preferred.
Remember, these are general guidelines. The specific dosage depends on several factors including the patient’s age, weight, overall health, and the severity of the infection. Regular monitoring of kidney function and potential side effects is necessary during treatment.
Important Note: This information is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before making any changes to your medication regimen.
