Both azithromycin and ciprofloxacin interact with several medications. Careful monitoring is needed when combining these antibiotics with other drugs.
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Medications Affecting Heart Rhythm
- Avoid combining with drugs that prolong the QT interval: This includes many antiarrhythmics (like amiodarone and quinidine), some antidepressants (like certain tricyclic antidepressants and some SSRIs), and some antipsychotics. These combinations increase the risk of dangerous heart rhythm disturbances. Consult your doctor: If you are taking any medications affecting heart rhythm, discuss the potential interactions with your physician before starting azithromycin or ciprofloxacin.
Other Notable Interactions
- Digoxin: Azithromycin can increase digoxin levels, leading to toxicity. Close monitoring of digoxin levels is necessary if both medications are used concurrently. Warfarin: Both azithromycin and ciprofloxacin can enhance the effects of warfarin, increasing the risk of bleeding. Regular blood tests are crucial to monitor INR levels. Theophylline: Ciprofloxacin can increase theophylline levels. This might lead to theophylline toxicity, which requires careful monitoring of blood levels. Antacids containing magnesium or aluminum: These can reduce the absorption of both azithromycin and ciprofloxacin, impacting their effectiveness. Separate administration by several hours is recommended.
Specific Medication Considerations
Always inform your physician and pharmacist: About all medications, including over-the-counter drugs, supplements, and herbal remedies, you are taking before starting azithromycin or ciprofloxacin. Review medication labels carefully: Understand potential drug interactions to minimise risks. Follow your doctor’s instructions precisely: Regarding both dosage and duration of treatment.
This information is not exhaustive, and individual responses to medications can vary. Always consult your doctor or pharmacist for personalized advice before combining medications.
