Prednisone, a corticosteroid, reduces inflammation in the body. In alopecia areata, it targets the immune system’s attack on hair follicles. This immunosuppressive effect allows hair regrowth by calming the inflammatory process responsible for hair loss.
Mechanisms of Action
- Decreases inflammation: Prednisone diminishes the inflammatory response, reducing the damage to hair follicles. Suppresses the immune system: By suppressing immune activity, Prednisone helps prevent further attacks on hair follicles. Promotes hair follicle cycling: The reduced inflammation allows hair follicles to transition back into the growth phase (anagen).
Treatment Considerations
Prednisone is usually prescribed as a short-term treatment due to potential side effects. Doctors often start with high doses, gradually tapering them down over several weeks or months. The specific dosage and duration depend on the severity of alopecia areata, individual response, and tolerance of the medication.
Potential Side Effects
Weight gain Increased appetite Mood changes High blood sugar Increased risk of infections Osteoporosis (with long-term use)
Regular monitoring by a dermatologist is necessary to assess treatment efficacy and manage potential side effects. Alternative therapies and combination treatments may be considered depending on the patient’s response to Prednisone.
Long-Term Outlook
Prednisone doesn’t provide a permanent cure for alopecia areata; hair loss may recur after stopping treatment. However, it can significantly improve hair regrowth in many cases, providing relief and improving quality of life during treatment.
Alternative Treatments
If Prednisone isn’t suitable or effective, various alternatives exist, including topical corticosteroids, immunotherapy, and other medications. Your doctor can help you explore other treatment options.
