Sildenafil troches can interact with several medications and substances. Always inform your doctor about all medications, supplements, and herbal remedies you are taking before starting sildenafil. This includes prescription and over-the-counter drugs.
Nitrates
Combining sildenafil with nitrates (found in medications for chest pain) can cause a dangerous drop in blood pressure. This combination is strictly contraindicated. Avoid using sildenafil if you’re taking any nitrate-containing medication.
Alpha-blockers
- Alpha-blockers, often prescribed for high blood pressure or enlarged prostate, can also lower blood pressure. Using sildenafil with alpha-blockers may cause dizziness or fainting. Your doctor might adjust your dosage or monitor your blood pressure closely if you need to take both medications.
CYP3A4 Inhibitors
Some medications inhibit the CYP3A4 enzyme, which metabolizes sildenafil. This can lead to increased sildenafil levels in your blood, potentially increasing side effects. Examples include ketoconazole, erythromycin, and ritonavir. Your doctor might need to lower your sildenafil dose.
CYP3A4 Inducers
Conversely, some medications induce CYP3A4, potentially decreasing sildenafil’s effectiveness. Rifampin is a notable example. Your doctor might need to adjust your sildenafil dosage accordingly.
Alcohol
Excessive alcohol consumption can worsen sildenafil’s side effects, such as dizziness and headaches. Moderate alcohol intake is generally acceptable, but you should discuss your alcohol consumption with your doctor.
Grapefruit Juice
Grapefruit juice inhibits CYP3A4, similar to some medications. Avoid grapefruit juice while taking sildenafil to prevent increased sildenafil levels.
Other Medications
Certain antidepressants (SSRIs, SNRIs) Some antihypertensives (besides alpha-blockers) Blood thinners
These medications can also interact with sildenafil. Always consult your doctor or pharmacist about potential interactions before taking sildenafil with any other medication.
Important Note:
This information is not exhaustive. This list provides examples of common interactions, but many other medications and substances could affect sildenafil’s efficacy or safety. Always consult with a healthcare professional before taking sildenafil, especially if you have pre-existing health conditions or are taking other medications.
