Mexiletine’s metabolism and effects can be altered by other medications. Concurrent use with drugs that inhibit CYP2D6, like fluoxetine or paroxetine, increases mexiletine levels, potentially leading to toxicity. Monitor your dog closely for signs of overdose, such as tremors or seizures.
Conversely, drugs that induce CYP2D6, such as rifampin, may decrease mexiletine levels, reducing its effectiveness. Regular monitoring of drug concentrations is advisable in such cases. Your veterinarian should adjust the dosage accordingly.
Mexiletine can interact with cardiac glycosides like digoxin, potentially increasing the risk of arrhythmias. Careful monitoring of the heart rhythm is necessary when these drugs are used together. Electrocardiograms may be frequently recommended.
Some antacids may reduce mexiletine absorption. Administer mexiletine at least two hours before or after antacid use. Consult your vet about optimizing medication timing to ensure proper drug absorption.
Always inform your veterinarian about all medications your dog is receiving, including over-the-counter drugs and supplements. This allows for the identification of potential interactions and enables proactive management of any potential complications.
