Erowid reports highlight several significant risks associated with tizanidine misuse. Low blood pressure (hypotension) is frequently mentioned, sometimes leading to fainting or dizziness. Users describe experiencing significant drowsiness and sedation, impairing their ability to drive or operate machinery safely. This effect is amplified when combined with other depressants like alcohol or opioids.
Liver Issues and Other Side Effects
Reports indicate potential liver problems following high-dose or prolonged tizanidine use. While rare, this serious complication warrants caution. Users also mention muscle weakness, nausea, and constipation. Some individuals experience anxiety or paradoxical reactions – unexpected effects opposite to the intended effect – such as increased anxiety instead of relaxation.
Withdrawal Symptoms and Dependence
Abrupt cessation after prolonged high-dose use can trigger withdrawal symptoms. Erowid reports describe symptoms including anxiety, insomnia, tremors, and muscle stiffness. The severity of withdrawal correlates with the dosage and duration of use. Developing a dependence on tizanidine is possible, emphasizing the need for careful monitoring and gradual dose reduction under medical supervision if cessation is necessary.
Mixing Tizanidine with Other Substances
Combining tizanidine with other central nervous system depressants poses a particularly high risk. This combination significantly increases the likelihood of respiratory depression, coma, and even death. Users should strictly avoid mixing tizanidine with alcohol, opioids, benzodiazepines, or other sedatives. Always inform your doctor about all medications and substances you use.
Seeking Medical Advice
If you are considering using tizanidine, consult a doctor. They can assess your health status, potential risks, and determine the appropriate dosage and monitoring strategy. If you experience any adverse effects, seek immediate medical attention. Remember, the information provided here is not a substitute for professional medical advice.
