Patients with impaired renal or hepatic function require dose adjustments for Zithromax (azithromycin). Always consult the prescribing information for precise guidance, as dosage modifications depend on the severity of impairment.
Renal Impairment
Azithromycin is primarily excreted unchanged in the bile, meaning renal impairment minimally affects its elimination. However, patients with severe renal dysfunction (creatinine clearance below 40 mL/min) may need a reduced dose. Closely monitor patients for adverse effects.
- Reduce the dose in severe renal impairment. Monitor for adverse reactions.
Hepatic Impairment
Azithromycin is metabolized in the liver. Patients with severe hepatic impairment should receive a lower dose of azithromycin or have their treatment duration shortened to mitigate the risk of accumulating azithromycin in the body, leading to increased adverse effects.
Lower the dose for patients with severe hepatic impairment. Consider shortening the treatment course. Close monitoring is advised.
Regularly assess renal and hepatic function during treatment, particularly in patients with pre-existing conditions. Adjust the dose or discontinue treatment as needed, based on clinical response and lab results. Always follow guidelines based on the latest prescribing information.
