Prednisone’s weight gain stems primarily from its impact on metabolism and fluid retention. It increases appetite, leading to increased calorie intake. This effect is mediated by the glucocorticoid receptors in the brain, affecting appetite regulation centers.
Furthermore, prednisone alters fat distribution. It promotes fat storage in the abdominal area (central obesity), a pattern linked to increased health risks. This redistribution is due to prednisone’s influence on enzymes that control fat metabolism.
Fluid retention contributes significantly. Prednisone increases sodium retention by the kidneys, causing water retention. This leads to a noticeable increase in body weight, often appearing as bloating or swelling.
The degree of weight gain varies, depending on factors such as dosage, duration of treatment, individual metabolism, and pre-existing conditions. Higher doses and longer treatment periods generally result in more significant weight gain.
| Increased Appetite | Glucocorticoid receptor activation in the brain | Higher Calorie Intake |
| Fat Redistribution | Altered fat metabolism enzymes | Central Obesity |
| Fluid Retention | Increased sodium retention by kidneys | Water weight gain, bloating |
Managing weight gain while on prednisone requires a multi-pronged approach including a balanced diet low in processed foods and refined sugars, regular exercise, and close monitoring by a healthcare professional. They can help adjust medication or provide additional strategies.
