Propranolol, especially the extended-release 120mg form, interacts with several medications. Always inform your doctor about all medications you take, including over-the-counter drugs and supplements.
Certain medications can significantly increase propranolol’s effects, potentially leading to dangerously low blood pressure or slow heart rate. These include calcium channel blockers (like verapamil or diltiazem), other beta-blockers, and certain antidepressants (like MAO inhibitors).
Conversely, some drugs can reduce propranolol’s effectiveness. These include rifampin (an antibiotic) and St. John’s Wort (a herbal supplement). Your doctor might need to adjust your propranolol dosage if you’re taking these medications.
The combination of propranolol with certain anesthetic agents can also cause problems. Always inform your anesthesiologist if you’re taking propranolol before any surgery.
Here’s a table summarizing potential interactions (this is not exhaustive, and always consult a medical professional):
| Calcium Channel Blockers | Verapamil, Diltiazem | Increased risk of bradycardia and hypotension |
| Other Beta-Blockers | Metoprolol, Atenolol | Additive effects, increased risk of bradycardia and hypotension |
| MAO Inhibitors | Phenelzine, Tranylcypromine | Increased risk of hypotension |
| Rifampin | Rifampin | Reduced propranolol effectiveness |
| St. John’s Wort | St. John’s Wort | Reduced propranolol effectiveness |
| Anesthetics | Various | Increased risk of hypotension and bradycardia |
This information is for educational purposes only and does not constitute medical advice. Always consult your physician or pharmacist for personalized guidance regarding drug interactions and medication management.
