Regularly monitor kidney function with blood tests measuring creatinine and eGFR (estimated glomerular filtration rate) at least annually, or more frequently if indicated by risk factors. Baseline testing is crucial before starting allopurinol.
Increased creatinine or decreased eGFR suggests potential kidney impairment. Consider adjusting allopurinol dosage or temporarily discontinuing treatment based on your doctor’s recommendations. Hydration is key; encourage patients to drink plenty of fluids.
Urine analysis helps detect early signs of kidney damage such as proteinuria (protein in urine). This test should also be performed routinely.
Patients with pre-existing kidney disease need close monitoring, potentially with more frequent testing (every 3 months or as clinically indicated). Careful dose adjustment is particularly important in this group.
Closely monitor for symptoms like decreased urine output, swelling in the legs and ankles, and unusual fatigue. These may signal kidney problems and necessitate immediate medical attention.
Regular communication with your doctor is paramount. Report any changes in your health status promptly. This proactive approach safeguards kidney health while managing gout effectively. Your doctor can guide you in the best course of action.
