If progesterone supplementation isn’t enough to resolve your infertility, your doctor might explore other medication options. These often target underlying hormonal imbalances contributing to low progesterone.
- Clomiphene Citrate (Clomid): This medication stimulates ovulation by increasing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) production. Increased LH can lead to higher progesterone production after ovulation. Typical treatment involves daily doses for 5 days, usually starting on cycle day 3-5. Your doctor will monitor your response closely. Letrozole: A non-steroidal aromatase inhibitor, Letrozole works similarly to Clomid, promoting ovulation by increasing FSH and LH. However, it’s generally better tolerated than Clomid by some individuals. Dosage and monitoring are crucial. Your doctor will guide your treatment plan. Gonadotropins: These injectable medications (like FSH and LH) directly stimulate ovarian follicle development and maturation, leading to higher chances of ovulation and, subsequently, improved progesterone levels. Gonadotropins require close monitoring via blood tests and ultrasounds to avoid overstimulation. Metformin: Primarily used for managing insulin resistance, Metformin can improve ovulation and progesterone levels in women with polycystic ovary syndrome (PCOS). It helps regulate insulin levels, which often play a significant role in hormonal imbalances contributing to infertility.
Remember, these medications have potential side effects. Discuss these thoroughly with your doctor before starting treatment. Your physician will tailor the medication choice and dosage based on your specific situation and test results. Regular monitoring is a vital part of successful treatment.
Discuss your medical history fully with your doctor. Undergo thorough testing to identify underlying causes of low progesterone. Follow your doctor’s instructions carefully regarding medication and monitoring appointments.


