Amoxicillin can interact with several medications. Always inform your dentist and doctor about all medications, supplements, and herbal remedies you’re taking, including over-the-counter drugs.
Oral Contraceptives
Amoxicillin may decrease the effectiveness of some oral contraceptives. Consider using a backup method of contraception while taking amoxicillin and for a week after you finish the course.
Anticoagulants (Blood Thinners)
Amoxicillin can potentially increase the effects of anticoagulants like warfarin. Close monitoring of your blood clotting time (INR) is recommended if you’re on anticoagulants. Your doctor may adjust your anticoagulant dosage.
Methotrexate
Concurrent use of amoxicillin and methotrexate can increase the risk of methotrexate toxicity. Your doctor should closely monitor you for side effects.
Probenecid
Probenecid interferes with the body’s elimination of amoxicillin, potentially leading to higher amoxicillin levels in your blood. This may increase the risk of side effects.
Other Medications
- Allopurinol: May increase the risk of skin reactions. Sulfonamides: May increase the risk of skin reactions.
This list isn’t exhaustive. Consult your healthcare provider for a complete assessment of potential drug interactions based on your specific health situation and medication profile.
Reporting Side Effects
If you experience any unusual symptoms while taking amoxicillin, such as severe allergic reactions (rash, swelling, difficulty breathing), gastrointestinal issues, or changes in your blood clotting, contact your doctor immediately.


