Sildenafil, marketed as Revatio for pulmonary arterial hypertension (PAH), works by inhibiting phosphodiesterase type 5 (PDE5). This inhibition increases levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in pulmonary blood vessels. This vasodilation reduces pulmonary vascular resistance, improving blood flow to the lungs and lessening the strain on the heart.
Dosage Recommendations
Dosage is individualized, starting low and gradually increasing based on response and tolerability. Typical starting doses range from 20mg three times daily.
- Initial Dose: Physicians often begin with 20mg three times daily. Dose Adjustments: Doses can be increased to a maximum of 80mg three times daily, depending on individual response and tolerance. Titration: Careful monitoring is crucial; dose adjustments are made gradually under a physician’s supervision.
Important Considerations
Before starting Revatio, discuss potential side effects with your doctor. Common side effects include headache, flushing, and dyspepsia. Serious side effects, though less common, may occur.
Monitoring: Regular check-ups are necessary to monitor blood pressure, heart function, and overall response to treatment. Interactions: Inform your doctor about all medications you are taking, including over-the-counter drugs, as interactions can occur. Contraindications: Revatio is contraindicated in certain conditions, including severe hepatic impairment and simultaneous use of nitrates.
Alternative PAH Treatments
Tadalafil (Adcirca), another PDE5 inhibitor, is also used to treat PAH. It offers a similar mechanism of action but may have a different dosage regimen and side effect profile.
Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting or changing any medication.
