Metformin typically starts at a low dose and gradually increases. A common starting dose is 500 mg once daily. Doctors often increase this to 500 mg twice daily after a week or two, if tolerated.
The maximum recommended daily dose is generally 2550 mg. However, this can vary based on individual factors, including kidney function. Higher doses are not always better and can increase the risk of side effects.
Titration, or gradual dose increase, is key to minimizing side effects like diarrhea, nausea, and abdominal discomfort. Many patients experience these early on, especially at higher doses. If side effects occur, your doctor might suggest reducing the dose temporarily or slowing the titration process.
Extended-release formulations of metformin are often prescribed to reduce gastrointestinal issues. These formulations release the medication more slowly, which helps minimize the impact on the digestive system. They usually require less frequent dosing.
| Immediate-release | 500 mg once daily | 2550 mg | Increase by 500 mg every 1-2 weeks as tolerated |
| Extended-release | 500 mg once daily | 2000 mg | Increase by 500 mg every 1-2 weeks as tolerated |
Always follow your doctor’s instructions regarding dosage and titration. Regular monitoring of kidney function is usually recommended, particularly with higher doses and extended use.
