Mirtazapine primarily works by blocking specific receptors in your brain. It’s a noradrenergic and specific serotonergic antidepressant (NaSSA). This means it affects the release of both norepinephrine and serotonin, neurotransmitters crucial for mood regulation.
Specifically, mirtazapine blocks presynaptic α2-adrenergic receptors. Blocking these receptors increases the release of both norepinephrine and serotonin into the synapse – the space between nerve cells where communication occurs. This increased availability of these neurotransmitters improves mood and reduces depressive symptoms.
Furthermore, mirtazapine also blocks 5-HT2 and 5-HT3 serotonin receptors. This action contributes to its antidepressant effects and helps minimize some of the side effects commonly associated with other antidepressants, such as nausea and anxiety.
The timing of mirtazapine’s administration – at bedtime – is significant. Its sedative effects are largely due to its action on histamine H1 receptors. Blocking these receptors promotes sleepiness, making bedtime administration convenient for many patients.
In summary: Mirtazapine enhances neurotransmitter activity, leading to improved mood, and its sedative properties facilitate better sleep.
