Tadalafil primarily treats pulmonary arterial hypertension (PAH) and erectile dysfunction (ED). It achieves this by inhibiting a specific enzyme, phosphodiesterase-5 (PDE5).
PDE5 breaks down cyclic guanosine monophosphate (cGMP), a molecule crucial for smooth muscle relaxation. By blocking PDE5, Tadalafil increases cGMP levels. This leads to vasodilation, widening blood vessels.
In PAH, this vasodilation improves blood flow to the lungs, reducing pressure. In ED, it enhances blood flow to the penis, facilitating erection.
| Pulmonary Arterial Hypertension (PAH) | Increased cGMP, leading to pulmonary vasodilation | Reduced pulmonary artery pressure, improved blood flow |
| Erectile Dysfunction (ED) | Increased cGMP, leading to penile vasodilation | Improved blood flow to the penis, facilitating erection |
Remember, individual responses to Tadalafil vary. Dosage should be determined by a healthcare professional, considering your medical history and current medications.
